Would global patent protection be too weak without international coordination?

I extend the Grossman and Lai (2004) model to answer the question, "Would global patent protection be too weak without international coordination?" by introducing firmbiased government preferences and trade barriers in the model. I make use of the estimates of the firm-bias parameter from the political economy literature to proxy for the degree of governments' firm-bias. Then I calculate the range of trade barriers that is sufficient to give rise to under-protection of patents in the global system without international policy coordination in IPR protection. I make the judgement that the true trade barrier between countries very likely falls within this range of under-protection. Therefore, I conclude that there was probably under-protection of patents without international policy coordination in IPR protection. It means that the free-rider problem with a large number of independent players overrides the effects of firm-bias and trade barriers, giving rise to too low a rate of innovation in the world. Allowing for the possibility that countries discriminate against foreign firms in Nash equilibrium does not change this conclusion. The problem can possibly be corrected by international coordination in intellectual property rights (IPR) protection.Intellectual property rights, TRIPS, Innovation

The most-favored nation rule in club enlargement negotiation

We study the effects of the Most-Favored Nation rule in an applicant's negotiation to join a club. When the applicant has to carry out a series of bilateral bargains with the existing members, we find that there are two effects of the MFN rule, viz. the hardened bargainer effect and the free-rider effect. The former effect tends to favor the applicant, while the latter effect tends to hurt the applicant. We find that the free-rider effect is stronger the more asymmetric are the members. The hardened bargainer effect is stronger the larger is the "size of the pie." As the number of members increase, it is more likely that the hardened bargainer effect would dominate.International trade ; Industrial organization (Economic theory) ; World Trade Organization

Surface temperature distribution along a thin liquid layer due to thermocapillary convection

The surface temperature distributions due to thermocapillary convections in a thin liquid layer with heat fluxes imposed on the free surface were investigated. The nondimensional analysis predicts that, when convection is important, the characteristics length scale in the flow direction L, and the characteristic temperature difference delta T sub o can be represented by L and delta T sub o approx. (A2Ma)/1/4 delta T sub R, respectively, where L sub R and delta sub R are the reference scales used in the conduction dominant situations with A denoting the aspect ratio and Ma the Marangoni number. Having L and delta sub o defined, the global surface temperature gradient delta sub o/L, the global thermocapillary driving force, and other interesting features can be determined. Numerical calculations involving a Gaussian heat flux distribution are presented to justify these two relations

A Theory of Government Procrastination

We present a theory to explain government procrastination as a consequence of its present-bias resulting from the political uncertainty in a two-party political system. We show that under a two-party political system the party in office tends to be present-biased. This may lead to inefficient procrastination of socially beneficial policies that carry upfront costs but yield long-term benefits. However, procrastination is often not indefinite even as we consider an infinite-horizon game. There exist equilibria in which the policy is implemented, and in many cases carried out to completion in finite time. When the net social benefit is large, there is no procrastination problem. When the net social benefit is small, the policy can be procrastinated indefinitely, though there may co-exist some gradual implementation equilibria. When the net social benefit is intermediate in magnitude, there are all sorts of procrastination equilibria, including gradual implementation. The theory predicts that a government with a more strongly predominant party tends to procrastinate less.present-bias, procrastination, policy implementation

International Protection of Intellectual Property

We study the incentives that governments have to protect intellectual property in a trading world economy. We consider a world economy with ongoing innovation in two countries that differ in market size, in their capacities for innovation, and in their absolute and comparative advantage in manufacturing. We associate the strength of IPR protection with the duration of a country's patents that are applied with national treatment. After describing the determination of national policies in a non-cooperative regime of patent protection, we ask, Why are patents longer in the North? We also study international patent agreements by deriving the properties of an efficient global regime of patent protection and asking whether harmonization of patent policies is necessary or sufficient for global efficiency.

New Production Mechanism of Neutral Higgs Bosons with Right scalar tau neutrino as the LSP

Motived by the neutrino oscillation data, we consider the lightest tau sneutrino $\tilde \nu_{\tau_1}$ (which is mostly the right tau sneutrino) to be the lightest supersymmetric particle (LSP) in the framework of the minimal supersymmetric Standard Model. Both the standard and the non-standard trilinear scalar coupling terms are included for the right tau sneutrino interactions. The decay branching ratio of $\tilde \nu_{\tau_2} \to \tilde \nu_{\tau_1}+ h^0$ can become so large that the production rate of the lightest neutral Higgs boson ($h^0$) can be largely enhanced at electron or hadron colliders, either from the direct production of $\tilde \nu_{\tau_2}$ or from the decay of charginos, neutralinos, sleptons, and the cascade decay of squarks and gluinos, etc. Furthermore, because of the small LSP annihilation rate, $\tilde \nu_{\tau_1}$ can be a good candidate for cold dark matter.Comment: 11 pages, RevTex, 3 eps figures. We clarify the theoretical framework of this study, with a note added in the end, and correct an equation, with updated figure

Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist

AIM: To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist. METHODS: Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios (IRR). RESULTS: Of 587 cirrhotics, 64% were male, median age (interquartile range) was 60 (53-64) years and MELD score was 15 (12-18). Median Fried Frailty Index was 2 (1-3); 31.6% were classified as frail (fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1 hospitalisation; 38% of which involved major infection. 107/184 (58%) frail and 142/399 (36%) non-frail patients were hospitalised at least once (P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year (IRR = 1.51, 95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender (IRR for frailty of 1.21, 95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty. CONCLUSION: In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity

Effect of a pedometer-based walking intervention on body composition in patients with ESRD: a randomized controlled trial.

BackgroundA randomized trial of a pedometer-based intervention with weekly activity goals led to a modest increase in step count among dialysis patients. In a secondary analysis, we investigated the effect of this intervention on body composition.MethodsSixty dialysis patients were randomized to standard care or a 6-month program consisting of 3 months of pedometers and weekly step count targets and 3 months of post-intervention follow-up. We obtained bioelectrical impedance spectroscopy (BIS) data on 54 of these patients (28 control, 26 intervention) and used linear mixed-modeling (adjusted for sex and dialysis modality) to estimate differences in change in total-body muscle mass (TBMM) adjusted for height2, fat mass (kg), and body mass index (BMI) (kg/m2) between control and intervention groups.ResultsThe median age of participants was 57.5 years (53-66), and 76% were men. At baseline, there was no significant difference between groups in age, BMI, race, or body composition, but there were more men in the intervention group. After 3 months, patients in the intervention group increased their average daily steps by 2414 (95% CI 1047, 3782) more than controls (p&nbsp;&lt; 0.001), but there were no significant differences in body composition. However, at 6 months, participants in the intervention had a significantly greater increase from baseline in TBMM of 0.7 kg/m2 (95% CI 0.3, 1.13), decrease in fat mass (- 4.3 kg [95% CI -7.1, - 1.5]) and decrease in BMI (- 1.0 kg/m2 [95% CI -1.8, - 0.2]) relative to controls. In post-hoc analysis, each increase of 1000 steps from 0 to 3 months was associated with a 0.3 kg decrease in fat mass (95% CI 0.05, 0.5) from 0 to 6 months, but there was no dose-response relationship with TBMM/ht2 or BMI.ConclusionA pedometer-based intervention resulted in greater decreases in fat mass with relative preservation of muscle mass, leading to a greater decrease in BMI over time compared with patients not in the intervention. These differences were driven as much by worsening in the control group as by improvement in the intervention group. Step counts had a dose-response relationship with decrease in fat mass.Trial registrationClinicalTrials.gov (NCT02623348). 02 December 2015